In short, yes. Check out this helpful blog post from the folks at Academic Life in Emergency Medicine – IV ceftriaxone for gonorrhea – sure.
It turns out the whole myth about the ‘depot effect’ of IM is just that – a myth. So feel free to give 1g of ceftriaxone IV if your gonorrhea addled patient has a line.
A couple of readers noted that they would give a dose of 250mg IV. I agree. 1g wouldn’t be harmful, but might be overkill.